c.1400, "backbone," later "thornlike part" (early 15c.), from Old French espine "thorn, prickle; backbone, spine" (12c., Modern French épine), from Latin spina "backbone," originally "thorn, prickle" (figuratively, in plural, "difficulties, perplexities"), from PIE *spe-ina-, from root *spei- "sharp point" (see spike, n.1). Meaning "the back of a book" is first attested 1922.