1530s, "fearful, timid," from Latin meticulosus "fearful, timid," literally "full of fear," from metus "fear, dread, apprehension, anxiety," of unknown origin. Sense of "fussy about details" is first recorded in English 1827, from French méticuleux "timorously fussy" [Fowler attributes this use in English to "literary critics"], from the Latin word. Related: Meticulosity.