Old English *fyxen (implied in adjective fyxan), fem. of fox (see fox, n. and cognate with Middle High German vühsinne, German füchsin). Solitary English survival of the Germanic feminine suffix -en, -in (also in Old English gyden "goddess;" mynecen "nun," from munuc "monk;" wlyfen "she-wolf," etc.). The figurative sense "ill-tempered woman" is attested from 1570s. The spelling shift from -f- to -v- began late 1500s (see V).