sulpha-
（〈美〉 sulfa-）
combining form
- in names of drugs derived from sulphanilamide［用于药名］表示“磺胺”, “磺胺（制）剂”。
词源
abbreviation of SULPHANILAMIDE .
1941 Pharm. Jrnl. 29 Nov. 188/3Sulphacetamide is a name which it has been proposed should be adopted for the preparation now known under the trade mark ‘Albucid’.
1975 Prescribers' Jrnl. XV. 139Sulphacetamide in the form of eye drops and ointment can produce sensitivity reactions on the skin around the eyes.
1940 R. O. Roblin et al. inJrnl. Amer. Chem. Soc. LXII. 2002/2In order to avoid possible confusion between sulfapyridine and sulfapyrimidine, the term sulfadiazines is suggested for these compounds. [ pyrimidine]
1943 . [ see sulphathiazole]
1956 I. L. Finar Org. Chem. II. xviii. 668Sulphadiazine..is less toxic than Sulphathiazole; it is the most widely used of the ‘sulpha’ drugs, its main use being for mild infections.
1980 Jrnl. Med. Microbiol. XIII. 131At therapeutic levels in blood, trimethoprim and sulphadiazine singly produced mainly a bactericidal action on pathogens responsible for urinary-tract infections.
1950 Brit. Med. Jrnl. 12 Aug. 409/1Sulphadimidine (‘sulphamezathine’) and Sulphamerazine ( U.S. P.) have almost identical qualities.
1961 . [ see sulfaquinoxalines.v. sulfa-]
1977 Martindale's Extra Pharmacopoeia ( ed. 27) 1479/2Sulphadimidine penetrates into cerebrospinal fluid less readily than sulphadiazine and is usually less effective than sulphadiazine in meningeal infections.
1961 Lancet 22 July 178/1 Rebollo..claimed a cure with sulphafurazole, given orally. [ for meningitis due to Pseudomonas pyocyanea]
1976 Ibid. 11 Dec. 1276/1,91 men with nongonococcal urethritis (N.G.U.) were randomly treated with..sulphafurazole (sulfisoxazole).
1941 Jrnl. Amer. Med. Assoc. 3 May 2019/2For 2-sulfanilamidopyrimidine it adopted the term sulfadiazine and for sulfanilylguanidine the term sulfaguanidine. [ sc. the Council on Pharmacy and Chemistry of the American Medical Association]
1943 Listener 16 Sept. 321/2 A quite new drug, sulphaguanidine, shows promise for the treatment of bacillary dysentery; it succeeds here..because much of it is not absorbed, and it therefore remains to act in the intestine.
1958 E. Newby Short Walk in Hindu Kush xviii. 220Everyone..was now suffering from dysentery. We all munched sulphaguanadine tablets but even these failed.
1977 Martindale's Extra Pharmacopoeia ( ed. 27) 1483/1Sulphaguanidine has been employed for the treatment of local intestinal infections..though it has now been largely superseded by the less toxic sulphonamides, phthalylsulphathiazole and succinylsulphathiazole.
1942 Lancet 30 May 639/1 In the summer of 1941 our attention was drawn by Drs. Martin and Rose of the research laboratories of Imperial Chemical (Pharmaceuticals) Ltd. to a near relation of sulphadiazine..to which the name sulphamethazine has been given.
1951 A. Grollman Pharmacol. & Therapeutics xxi. 434Sulfamethazine.., the methyl derivative of sulfamerazine resembles the latter in action and is used for the same purposes as sulfamerazine and sulfadiazine.
1965 Pharmacopeia U.S. A. (ed. 17) 785U.S. P. XVII Title..Sulfamethazine. Other Designation(s)... Sulphadimidine (BP).
1978 Spinelli & Enos Drugs inVet. Pract. x. 135/1Foot rot... The following can be used: 1. Sulfamethazine, starting with one intravenous injection . [ etc.]
1952 Chem. Abstr. XLVI. 686Sulfathiazole, sulfadiazine, and sulfamethizole have been detd. by this method in various pharm. prepns.
1977 Lancet 16 Apr. 863/2 Sulphamethizole and alkali were prescribed pending a culture report.
1960 Antibiotics & Chemotherapy ( N.Y. ) X. 572A new sulfonamide compound, sulfamethoxazole, is identified chemically as 5-methyl-3-sulfanilamidoisoxazole.
1977 Lancet 2 July 4/1 Much of the shigellosis could be successfully treated with ampicillin trihydrate and closely related antibiotics, or with co-trimoxazole (trimethoprim and sulphamethoxazole).
1981 H. J. Rogers et al.Textbk. Clin. Pharmacol. xix. 653Sulphamethoxazole is about 50% metabolised so that much reaches the urine in an inactive form.
1956 Antibiotic Med. &Clin. Therapy III. 386A new antibacterial sulfonamide, sulfamethoxypyridazine, has been studied in 67 patients.
1980 Biochem. Pharmacol. XXIX. 984/1Kidney weight/body weight ratio, DNA and protein concentrations of kidney cortex were determined in 55-day-old rats repeatedly pretreated with saline, PAH, sulfamethoxypyridazine, cyclopenthiazide and phenobarbital, respectively.
1943 Trade Marks Jrnl. 6 Oct. 421/2Sulphamezathine... Pharmaceutical organic substances being sulphanilamido compounds for veterinary use. Imperial Chemical (Pharmaceuticals) Ltd.
1944 Pharmaceutical Jrnl. 8 Apr. 154a/3Imperial Chemicals (Pharmaceuticals), Ltd., now offer their ‘Sulphamezathine’ brand of sulphadimethylpyrimidine in the form of a stable solution of the sodium salt.
1970 Country Life 26 Feb. 491/1 The drinking water should be dosed with sulphamezathine to prevent coccidiosis.
1939 Jrnl. Amer. Med. Assoc. 7 Jan. 49/2Recent reports from investigators indicate that a pyridine derivative of sulfanilamide..is apparently more promising in the treatment of certain types of pneumonia than sulfanilamide itself... The Council has therefore adopted the term ‘sulfapyridine’.
1942 Times 30 Nov. 2/3 In 1939, by skilled use of the new drug sulphapyridine, it was brought down to 33 per [ sc. the fatality rate in spotted fever] cent.
1957 . [ see M and B]
1967 . [ see sulphanilamide]
1981 H. J. Rogers et al.Textbk. Clin. Pharmacol. xix. 649Sulphapyridine in low doses over prolonged periods may control dermatitis herpetiformis.
1948 Trade Marks Jrnl. 12 May 348/2Sulphatriad... Pharmaceutical preparations of sulphonamides... May & Baker Limited... Manufacturing chemists.
1950 ‘N. Shute’ Town like Alice vi. 184The flies would probably result in dysentery but she knew what to do about that; she had plenty of sulphatriad.
1968 J. H. Burn Lect. NotesPharmacol. (ed. 9) 101If three sulphonamides are used together, as in Sulphatriad, only one-third of the amount of each need be used.
1965 Pharmacopeia U.S. A. (ed. 17) 785U.S. P. XVII Title... Sulfisoxazole. Other Designation(s)... Sulphafurazole (BP).
1976 . [ see sulphafurazole above]
1977 Lancet 2 July 4/1 Most of the S. flexneri strains were resistant to tetracycline, streptomycin, and sulphafurazole diethanolamine (sulfisoxazole dialomine).
1952 H. Beckman Pharmacol. inClin. Pract. 648The principal ones in current use are sulfadiazine, sulfamerazine, Sulfamethazine..and sulfisoxazole. [ sc. sulphonamides]
ORIGIN: Abbreviation of sulpha(nilamide
sulpha-
or sulph-
— see sulfa-
or sulph-
— see sulfa-
sulpha-
Prefix
- Alternative spelling of sulfa-
- dated, chemistry sulfur compounds