1816, "pertaining to the brain," from French cérébral (16c.), from Latin cerebrum "the brain" (also "the understanding"), from PIE *keres-, from root *ker- (1) "top of the head" (see horn, n.). Meaning "intellectual, clever" is from 1929. Cerebral palsy attested from 1824, originally a general term for cases of paralysis that seemed to be traceable to "a morbid state of the encephalon." Later used in a more specific sense from c.1860, based on the work of English surgeon Dr. William Little.