1799, "to accuse, bring charges against," from Medieval Latin inculpatus, past participle of inculpare "to reproach, blame, censure," from Latin in- "in" (see in-(2)) + culpare "to blame," from culpa "fault." But inculpable (late 15c.) means "not culpable, free from blame," from Latin in- "not" (see in-(1)) + culpare.