1520s, from Middle French gargouiller "to gurgle, bubble" (14c.), from Old French gargole "throat, waterspout," which is perhaps from garg-, imitative of throat sounds, + *goule, dialect word for "mouth," from Latin gula "throat." Related: Gargled; gargling. The earlier, native, form of the word was Middle English gargarize (early 15c.), from Latin gargarizare, from Greek gargarizein.

1650s, "liquid used in gargling," from gargle, v..